Tuesday, March 5, 2013

CANNABINOIDS Slow Cancer Growth

Mounting evidence shows ‘cannabinoids’ in marijuana slow cancer growth, inhibit formation of new blood cells that feed a tumor, and help manage pain, fatigue, nausea, and other side effects.

 
Cristina Sanchez, a young biologist at Complutense University in Madrid, was studying cell metabolism when she noticed something peculiar. She had been screening brain cancer cells because they grow faster than normal cell lines and thus are useful for research purposes. But the cancer cells died each time they were exposed to tetrahydrocannabinol (THC), the principal psychoactive ingredient of marijuana.
Instead of gaining insight into how cells function, Sanchez had stumbled upon the anti-cancer properties of THC. In 1998, she reported in a European biochemistry journal that THC “induces apoptosis [cell death] in C6 glioma cells,” an aggressive form of brain cancer. 
Subsequent peer-reviewed studies in several countries would show that THC and other marijuana-derived compounds, known as “cannabinoids,” are effective not only for cancer-symptom management (nausea, pain, loss of appetite, fatigue), they also confer a direct antitumoral effect
A team of Spanish scientists led by Manuel Guzman conducted the first clinical trial assessing the antitumoral action of THC on human beings. Guzman administered pure THC via a catheter into the tumors of nine hospitalized patients with glioblastoma, who had failed to respond to standard brain-cancer therapies. The results were published in 2006 in the British Journal of Pharmacology: THC treatment was associated with significantly reduced tumor cell proliferation in every test subject
Around the same time, Harvard University scientists reported that THC slows tumor growth in common lung cancer and “significantly reduces the ability of the cancer to spread.” What’s more, like a heat-seeking missile, THC selectively targets and destroys tumor cells while leaving healthy cells unscathed. Conventional chemotherapy drugs, by contrast, are highly toxic; they indiscriminately damage the brain and body.
There is mounting evidence, according to a report in Mini-Reviews in Medicinal Chemistry, that cannabinoids “represent a new class of anticancer drugs that retard cancer growth, inhibit angiogenesis [the formation of new blood cells that feed a tumor] and the metastatic spreading of cancer cells.”
Dr. Sean McAllister, a scientist at the Pacific Medical Center in San Francisco, has been studying cannabinoid compounds for 10 years in a quest to develop new therapeutic interventions for various cancers. Backed by grants from the National Institute of Health (and with a license from the DEA), McAllister discovered that cannabidiol (CBD), a nonpsychoactive component of the marijuana plant, is a potent inhibitor of breast cancer cell proliferation, metastasis, and tumor growth. 
In 2007, McAllister published a detailed account of how cannabidiol kills breast cancer cells and destroys malignant tumors by switching off expression of the ID-1 gene, a protein that appears to play a major role as a cancer cell conductor. 
The ID-1 gene is active during human embryonic development, after which it turns off and stays off. But in breast cancer and several other types of metastatic cancer, the ID-1 gene becomes active again, causing malignant cells to invade and metastasize. “Dozens of aggressive cancers express this gene,” explains McAllister. He postulates that CBD, by virtue of its ability to silence ID-1 expression, could be a breakthrough anti-cancer medication. 
“Cannabidiol offers hope of a non-toxic therapy that could treat aggressive forms of cancer without any of the painful side effects of chemotherapy,” says McAllister, who is seeking support to conduct clinical trials with the marijuana compound on breast cancer patients.

McAllister’s lab also is analyzing how CBD works in combination with first-line chemotherapy agents. His research shows that cannabidiol, a potent antitumoral compound in its own right, acts synergistically with various anti-cancer pharmaceuticals, enhancing their impact while cutting the toxic dosage necessary for maximum effect. 
cancer-cells-marijuana-lee
Breast cancer cells killed by CBD on right compared to untreated breast cancer cells on left.
(Courtesy Pacific Medical Center)
“Cannabidiol offers hope of a non-toxic therapy that could treat aggressive forms of cancer without any of the painful side effects of chemotherapy.
Investigators at St. George’s University in London observed a similar pattern with THC, which magnified the effectiveness of conventional antileukemia therapies in preclinical studies. THC and cannabidiol both induce apoptosis in leukemic cell lines. 
At the annual summer conference of the International Cannabinoid Research Society, held this year in Freiburg, Germany, 300 scientists from around the world discussed their latest findings, which are pointing the way toward novel treatment strategies for cancer and other degenerative diseases. Italian investigators described CBD as “the most efficacious inducer of apoptosis” in prostate cancer. Ditto for cannabidiol and colon cancer, according to British researchers at Lancaster University. 
Within the medical science community, the discovery that cannabinoids have anti-tumoral properties is increasingly recognized as a seminal advancement in cancer therapeutics.
Source: The Daily Beast

3 comments:



  1. OMG""""ALTHOUGH WORDS ARE NOT ENOUG TO THANK DR ZACK FOR SAVING MY WIFE FROM DYING OF CANCER DISEASE"""
    My wife was diagnosed of prostrate cancer few months ago by doctor, And advised we use a high frequency treatment that is not available in URUGUAY, and couldonly be done in BELARUS at the cost of [31,000] euro which i could not afford with my present financial situation so i started looking for a quicker alternative, i contacted a co-worker who,s wife have experience such situation and came out of it under few months to know the solution which he told me that the situation was brought under control and normal till date by just using DR.ZACK CANNABIS OIL, Instantly i contacted DR.ZACK and in 48 hours i have gotten the cannabis oil in my country which my wife started applying it immediately, soonest she regain her appetite, That was the first benefit that we noticed. She was happier, she smiled and laughed constantly. We loved it! One week after we began the oil treatment the physicians notified us that her leukemia had vanished from her bone marrow and blood! She was in remission. Never again will I fear cancer. We found the answer! my wife is currently 3 months into the intense treatment part and has never used any pain relievers (not even Tylenol) and has only had to take anti-nausea medication a few times. you can contact him via his email address EVOLUTIONSPELLTEMPLE@YAHOO.COM



    OMG""""ALTHOUGH WORDS ARE NOT ENOUG TO THANK DR ZACK FOR SAVING MY WIFE FROM DYING OF CANCER DISEASE"""
    My wife was diagnosed of prostrate cancer few months ago by doctor, And advised we use a high frequency treatment that is not available in URUGUAY, and couldonly be done in BELARUS at the cost of [31,000] euro which i could not afford with my present financial situation so i started looking for a quicker alternative, i contacted a co-worker who,s wife have experience such situation and came out of it under few months to know the solution which he told me that the situation was brought under control and normal till date by just using DR.ZACK CANNABIS OIL, Instantly i contacted DR.ZACK and in 48 hours i have gotten the cannabis oil in my country which my wife started applying it immediately, soonest she regain her appetite, That was the first benefit that we noticed. She was happier, she smiled and laughed constantly. We loved it! One week after we began the oil treatment the physicians notified us that her leukemia had vanished from her bone marrow and blood! She was in remission. Never again will I fear cancer. We found the answer! my wife is currently 3 months into the intense treatment part and has never used any pain relievers (not even Tylenol) and has only had to take anti-nausea medication a few times. you can contact him via his email address EVOLUTIONSPELLTEMPLE@YAHOO.COM

    ReplyDelete

  2. OMG""""ALTHOUGH WORDS ARE NOT ENOUG TO THANK DR ZACK FOR SAVING MY WIFE FROM DYING OF CANCER DISEASE"""
    My wife was diagnosed of prostrate cancer few months ago by doctor, And advised we use a high frequency treatment that is not available in URUGUAY, and couldonly be done in BELARUS at the cost of [31,000] euro which i could not afford with my present financial situation so i started looking for a quicker alternative, i contacted a co-worker who,s wife have experience such situation and came out of it under few months to know the solution which he told me that the situation was brought under control and normal till date by just using DR.ZACK CANNABIS OIL, Instantly i contacted DR.ZACK and in 48 hours i have gotten the cannabis oil in my country which my wife started applying it immediately, soonest she regain her appetite, That was the first benefit that we noticed. She was happier, she smiled and laughed constantly. We loved it! One week after we began the oil treatment the physicians notified us that her leukemia had vanished from her bone marrow and blood! She was in remission. Never again will I fear cancer. We found the answer! my wife is currently 3 months into the intense treatment part and has never used any pain relievers (not even Tylenol) and has only had to take anti-nausea medication a few times. you can contact him via his email address EVOLUTIONSPELLTEMPLE@YAHOO.COM



    OMG""""ALTHOUGH WORDS ARE NOT ENOUG TO THANK DR ZACK FOR SAVING MY WIFE FROM DYING OF CANCER DISEASE"""
    My wife was diagnosed of prostrate cancer few months ago by doctor, And advised we use a high frequency treatment that is not available in URUGUAY, and couldonly be done in BELARUS at the cost of [31,000] euro which i could not afford with my present financial situation so i started looking for a quicker alternative, i contacted a co-worker who,s wife have experience such situation and came out of it under few months to know the solution which he told me that the situation was brought under control and normal till date by just using DR.ZACK CANNABIS OIL, Instantly i contacted DR.ZACK and in 48 hours i have gotten the cannabis oil in my country which my wife started applying it immediately, soonest she regain her appetite, That was the first benefit that we noticed. She was happier, she smiled and laughed constantly. We loved it! One week after we began the oil treatment the physicians notified us that her leukemia had vanished from her bone marrow and blood! She was in remission. Never again will I fear cancer. We found the answer! my wife is currently 3 months into the intense treatment part and has never used any pain relievers (not even Tylenol) and has only had to take anti-nausea medication a few times. you can contact him via his email address EVOLUTIONSPELLTEMPLE@YAHOO.COM

    ReplyDelete
  3. All thanks goes to Dr. Koffi for providing me with cannabis oil here in the United State of America. I was diagnose with skin and prostrate cancer one year, and ever since then i have done a lot of Chemo and Radiation that have not help me, but only damaged my immune system and render me weak and helpless. I came across the cannabis oil and i have read about the oil a lot and saw the Post that Dr. Koffi could provide me with cannabis Oil here is the State for the procurement of this medication, to my surprise the medication was procured and delivered within 3 days and i have been on treatment for the past one months. Am now here to testify that am no longer a cancer patient. I have experience a total transformation in my life with Dr. Koffi cannabis oil service. It worked exactly as the he prescribed it. Thanks to Dr, Koffi for taking away sorrow in my life. For all cancer patients that lives in American region, Asia and Europe at large, go get your cannabis oil by contacting Dr. Koffi @ (Ultimatecancercure@yahoo.com)

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