68 studies on the efficiency of marijuana against cancer
Mechanisms of cannabinoid action against brain tumors
Cancer is a leading cause of death in industrialised countries. So far, the treatments available from the pharmaceuticals mostly have limited efficiency, as well as a significant toxicity and strong undesirable side effects. It is known that the marijuana plant can help in a natural way and relieve symptoms of cancer and chemotherapy: pain relief, nausea, vomiting, greater appetite, improvement of mood, sleep, relationships with the environment… And we all know how important it is to have a good quality of life when fighting against any disease.
New studies show efficiency of Cannabis against Cancer (2013)
Therefore, we can now find something even more interesting: some cannabinoids in the marijuana plant have a healing action against different forms of cancer. Several testimonies are available now in social networks, particularly in the United States, where medical marijuana is much more accessible than in Europe. Examples of the most common cures are leukemia and brain tumors (gliomas), usually in children and even babies. However, these numerous testimonies are not sufficient evidence to convince the medical and scientific communities, which need reliable studies to confirm these claims. In order to rectify the situation, we propose here a (non-exhaustive) list of 68 international scientific publications, drawn from the best research laboratories, demonstrating the efficiency of the cannabinoids found in marijuana plants in the treatment of cancer.
Diagram of the cannabinoid action against cancer cells
Studies on the action of cannabinoids against cancer
Anti-tumor effects of marijuana. Updated publications on the website of the National Cancer Institute of the Government of the United States in May 2014.
Preparation and characterisation of biodegradable microparticles filled with THC and their antitumor efficacy on cancer cell lines. Study published in the Journal of Drug Targeting in September 2013.
The endocannabinoid system: a therapeutic target for regulating the growth of cancer.
Pr. Manuel Guzman, Cannabis vs Cancer: THC, CBD and TMZ (2014)
Marijuana against brain cancer (glioma, glioblastoma…)
Cannabidiol (CBD), a non-psychoactive cannabinoid compound, inhibits the proliferation and invasion in U87-MG and T98G glioma cells through a multitarget effect. Study published in the Public Library of Science journal in October 2013.
CBD, a novel therapeutic target against glioblastoma. Study published in Cancer Research in March 2013.
Local delivery of cannabinoid-filled microparticles inhibits tumor growth in a model of glioblastoma multiforme. Study published in Public Library of Science in January 2013.
Cannabinoid action inhibits the growth of malignant human glioma U87MG cells. Study published in Oncology Reports in July 2012.
A combined preclinical therapy of cannabinoids and temozolomide against glioma. Study published in Molecular Cancer Therapeutics in January 2011.
Cannabidiol enhances the inhibitory effects of THC on human glioblastoma cell proliferation and survival. Study published in the Molecular Cancer Therapeutics journal in January 2010.
A pilot clinical study of THC in patients with recurrent glioblastoma multiforme. The results were published in the British Journal of Cancer in June 2006.
Cannabidiol inhibits human glioma cell migration through an independent cannabinoid receptor mechanism. Study published in the British Journal of Pharmacology in April 2005.
Cannabinoids inhibit the vascular endothelial growth factor pathway (VEGF) in gliomas. Study published in the Journal of Cancer Research in August 2004.
Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines. Study published in the Journal of Pharmacology in November 2003.
Inhibition of glioma growth in vivo by selective activation of the CB2 cannabinoid receptor. Study published in the Journal of Cancer Research in August 2001.
Mechanisms of cannabinoid action against brain tumors
Marijuana against breast cancer
Targeting multiple cannabinoid antitumor pathways with a resorcinol derivative leads to inhibition of advanced stages of breast cancer. Study published in the British Journal of Pharmacology in June 2014.
CBDA, an acid form of CBD found in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration. Study published in Toxicology Letters in November 2012.
Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of Icam-1. Study published in Biochemical Pharmacology in July 2014.
Cannabinoids inhibit angiogenic capacities of endothelial cells via release of tissue inhibitor of matrix metalloproteinases-1 from lung cancer cells. Study published in Biochemical Pharmacology in June 2014.
Bile duct: The dual effects of THC on cholangiocarcinoma cells: anti-invasion activity at low concentration and apoptosis induction at high concentration. Study published in Cancer Investigation in May 2010.
Finally, it’s worth highlighting from these publications that the efficacy of cannabinoids against cancer depends on the dose: the higher the dose, the more important the action. Since it is difficult to obtain high and constant blood concentrations of cannabinoids by consuming marijuana plants in the usuall ways (smoking, vaporizing…) most patients use extractions of cannabinoids. The most popular extraction is called Rick Simpson’s oil .
Efficiency of cannabinoids against cancer
We advise you to use a high CBD marijuana strain for your extractions, for this non-psychoactive cannabinoid seems to be the one with best anti-tumor properties.
We greatly appreciate the research work carried out by Dr Manuel Guzman’s team at the Universidad Complutense de Madrid for their current work on the use of cannabinoids against cancer.
Do not hesitate to share this information in your community, particularly if you know doctors who do cancer research, and obviously with people suffering from this disease and seeking a natural, effective and safe complementary therapy.
The current legislation on medical marijuana is not adapted to the medical information available today.